Rare diseases · Sign or symptom

Abnormal circulating adrenocorticotropin concentration

HP:0011043

What it means

An abnormal concentration of corticotropin in the blood.

Adrenocorticotropic hormone (ACTH), also known as corticotropin, is a polypeptide hormone produced and secreted by the pituitary gland comprising 39 amino acid residues coupled in a linear sequence. . It is a component of the hypothalamic-pituitary-adrenal axis and stimulates increased production and release of corticosteroids and cortisol from the adrenal cortex.

Rare diseases that can present with this2

Sometimes5–29%

1

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Abnormality of circulating ACTH level · Abnormality of circulating adrenocorticotropic hormone level · Abnormality of circulating adrenocorticotropin level · Abnormality of circulating corticotropin level

Abnormal circulating adrenocorticotropin…

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.