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Start free with EleplanPost-selective serotonin reuptake inhibitor sexual dysfunction
ORPHA:686475Disease
Also called PSSD · Post-SSRI sexual dysfunction
What it is
A rare neurologic disease characterized by persistent side effects of depression treatment with selective serotonin reuptake inhibitors (SSRIs) manifests as a range of sexual and reproductive dysfunctions. Commonly experienced clinical signs in (male) patients include the triad of genital anesthesia, decreased or lost libido, and erectile dysfunction, as well as weak or pleasureless orgasm, premature ejaculation, reduced penile size, decreased seminal volume, and testicular atrophy or pain. In female patients, additional manifestations may include vaginal lubrication difficulties, irregular menstruation, and nipple insensitivity. These symptoms may begin days or weeks after initiation of treatment and can persist even after the medication is discontinued, significantly impacting quality of life.
Key facts
- Inheritance
- Not applicable
- Classified as
- Disease
ICD-10 codes
ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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