Post 5-alpha-reductase inhibitors…

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Post 5-alpha-reductase inhibitors treatment syndrome

ORPHA:686468Disease

What it is

A rare neurologic disease characterized by persistent side effects of terminated 5-alpha-reductase inhibitor treatment, including impaired sexual function (low libido, erectile dysfunction, diminished semen volume and force), genital numbness or paresthesia, gynecomastia, depression, brain fog and elevated anxiety. Additional symptoms may include muscular problems (tics, muscle spasms, tremors, involuntary muscle contraction and muscular ache), joint pain, chronic fatigue, migraine, decreased body temperature and dry skin.

Key facts

Inheritance
Not applicable
Classified as
Disease

ICD-10 codes

F52.8filed under a broader ICD-10 category — shared with 1 other rare disease

ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.

Related health topics

Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.

Cross-references

MONDO 975897

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.

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