Non-immune hydrops fetalis

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Non-immune hydrops fetalis

ORPHA:363999Clinical subtype

Also called Non-immune HF · Non-immune fetal edema · Non-immune fetal hydrops · NIHF

What it is

Non-immune hydrops fetalis (NIHF), a form of HF, is a severe fetal condition defined as the excessive accumulation of fetal fluid within the fetal extravascular compartments and body cavities, and is the end-stage of a wide variety of disorders.

Key facts

Prevalence
>1 / 1000 (Thailand)
Age of onset
Antenatal, Neonatal
Inheritance
Not applicable
Classified as
Clinical subtype

Prevalence figures describe populations, not individuals, and are often estimates from a single study. Where the figure is an incidence or a birth prevalence, it says so.

Genes

ANGPT2Disease-causing germline mutation(s) (loss of function)
CALCRLDisease-causing germline mutation(s)
THSD1Disease-causing germline mutation(s)

ICD-10 codes

P83.2ICD-10 names this disease exactly — shared with 2 other rare diseases

ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.

Cross-references

MONDO 0009369OMIM 236750OMIM 618773OMIM 619369OMIM 620244UMLS C0455988

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.

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