Rare diseases · Sign or symptom
Limitation of joint mobility
Decreased joint mobility
HP:0001376
What it means
A reduction in the freedom of movement of one or more joints.
Rare diseases that can present with this117
Very common80–99%
40- Arginine vasopressin resistance-intracranial calcification-short stature-facial dysmorphism syndrome
- Atypical Werner syndrome
- Autosomal recessive multiple pterygium syndrome
- Blau syndrome
- Contractures-ectodermal dysplasia-cleft lip/palate syndrome
- Cutis laxa-Marfanoid syndrome
- Felty syndrome
- Fibrodysplasia ossificans progressiva
- Fibular aplasia-complex brachydactyly syndrome
- German syndrome
- Hurler-Scheie syndrome
- Hurler syndrome
- Hypomyelination neuropathy-arthrogryposis syndrome
- Intellectual disability, Wolff type
- Isolated humero-radial synostosis
- Kagami-Ogata syndrome
- Kienbock disease
- Lethal intrauterine growth restriction-cortical malformation-congenital contractures syndrome
- Mandibuloacral dysplasia with type A lipodystrophy
- Mesomelic dysplasia, Nievergelt type
- Microphthalmia-microtia-fetal akinesia syndrome
- Microtriplication 11q24.1 syndrome
- Mucopolysaccharidosis type 2
- Multicentric carpo-tarsal osteolysis with or without nephropathy
- Nasu-Hakola disease
- Ophthalmomandibulomelic dysplasia
- Osteochondritis dissecans
- Otopalatodigital syndrome type 1
- PAPA syndrome
- Pelvic dysplasia-arthrogryposis of lower limbs syndrome
- Pfeiffer syndrome type 2
- Pfeiffer syndrome type 3
- Progressive osseous heteroplasia
- Rhizomelic syndrome, Urbach type
- Scheie syndrome
- Self-improving collodion baby
- Spondyloepimetaphyseal dysplasia, Irapa type
- Stiff skin syndrome
- Trismus-pseudocamptodactyly syndrome
- Wieacker-Wolff syndrome
Common30–79%
40- 8q22.1microdeletion syndrome
- Atherosclerosis-deafness-diabetes-epilepsy-nephropathy syndrome
- Atypical teratoid rhabdoid tumor
- Aymé-Gripp syndrome
- Bohring-Opitz syndrome
- Brachydactylous dwarfism, Mseleni type
- Camurati-Engelmann disease
- Congenital muscular dystrophy due to LMNA mutation
- Crisponi syndrome
- C syndrome
- Dracunculiasis
- Dyssegmental dysplasia, Silverman-Handmaker type
- Extensor tendons of finger anomalies
- Filippi syndrome
- Geleophysic dysplasia
- Harlequin ichthyosis
- Hutchinson-Gilford progeria syndrome
- Intellectual disability-myopathy-short stature-endocrine defect syndrome
- Kyphomelic dysplasia
- Laurin-Sandrow syndrome
- Lethal congenital contracture syndrome type 1
- Monosomy 9p syndrome
- Mosaic trisomy 8 syndrome
- Mosaic trisomy 9 syndrome
- Mucolipidosis type II
- Multiple epiphyseal dysplasia type 4
- Multiple osteochondromas
- Myalgia-eosinophilia syndrome associated with tryptophan
- Oculocerebral hypopigmentation syndrome, Cross type
- Pachydermoperiostosis
- PEHO syndrome
- Progressive pseudorheumatoid dysplasia
- Relapsing polychondritis
- Rheumatoid factor-positive polyarticular juvenile idiopathic arthritis
- Rhizomelic chondrodysplasia punctata
- Secondary non-traumatic avascular necrosis
- Short stature-craniofacial anomalies-genital hypoplasia syndrome
- Spondyloepiphyseal dysplasia tarda
- Spondylometaphyseal dysplasia, 'corner fracture' type
- Stüve-Wiedemann syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Decreased mobility of joints · Limited joint mobility · Limited joint motion
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.