Acute fatty liver of pregnancy

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Acute fatty liver of pregnancy

ORPHA:243367Disease

Also called AFLP

What it is

A rare, severe complication occurring in the third trimester of pregnancy or in early postpartum period bearing a risk for perinatal and maternal mortality and characterized by jaundice, rise of hepatic injuries and evolving to acute liver failure and encephalopathy.

Key facts

Age of onset
Adult
Inheritance
Multigenic/multifactorial
Classified as
Disease

Gene

HADHADisease-causing germline mutation(s)

ICD-10 codes

O26.6filed under a broader ICD-10 category — shared with 1 other rare disease

ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.

Related health topics

Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.

Cross-references

GARD 9578MEDDRA 10000746MESH C537957MONDO 0016573UMLS C1455728

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.

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