Clinical drug
lactate 26.4 MG/ML Topical Solution [Encore]
26.4 MG/ML · Topical Solution · topical
A form of lactate →
lactate 26.4 MG/ML Topical Solution [Encore] — Organic acids. INDICATIONS AND USAGE Ammonium Lactate Lotion, 12% is indicated for the treatment of dry, scaly skin (xerosis) and ichthyosis vulgaris, and for the te
![lactate 26.4 MG/ML Topical Solution [Encore]](https://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=4c2f052b-7ba2-4122-a50b-37ef2a834d61&name=milrinone-lactate-in-dextrose-injection-1.jpg)
Active ingredient
Classification
Organic acids
Drug interactions
The label outlines several drug interactions with Potassium Chloride in Lactated Ringer’s and Dextrose (5%) Injection.
- majordrugs that affect electrolyte and/or fluid balance — increased risk of severe and potentially fatal hyperkalemia
- majorlithium — decreased lithium concentrations
- majordigoxin — increased risk of digoxin toxicity including serious or fatal cardiac arrhythmias
- majordrugs associated with hyponatremia (e.g., diuretics, arginine vasopressin analogs) — increased risk of developing hyponatremia
- majorthiazide diuretics or vitamin D — increased risk of hypercalcemia
- majordrugs associated with sodium and fluid retention (e.g., corticosteroids) — increased risk of hypernatremia and volume overload
- moderatedrugs with pH-dependent renal elimination — interference with renal clearance of drugs
Real-world adverse events (FAERS)
Death8,361Peritonitis3,892Peritonitis Bacterial2,529Drug Ineffective2,426Hypotension2,242Pneumonia1,946Dyspnoea1,814Vomiting1,768
Indications
INDICATIONS AND USAGE Ammonium Lactate Lotion, 12% is indicated for the treatment of dry, scaly skin (xerosis) and ichthyosis vulgaris, and for the temporary relief of itching associated with these conditions.
Dosage
DOSAGE AND ADMINISTRATION Shake well. Apply to the affected areas and rub in thoroughly. Use twice daily or as directed by a physician.
Warnings
WARNING Sun exposure (natural or artificial sunlight) to areas of the skin treated with Ammonium Lactate Lotion, 12% should be minimized or avoided (see PRECAUTIONS ). The use of Ammonium Lactate Lotion, 12% should be discontinued if any hypersensitivity is observed.
Contraindications
CONTRAINDICATIONS Ammonium Lactate Lotion, 12% is contraindicated in those patients with a history of hypersensitivity to any of the label ingredients.
Mechanism of action
CLINICAL PHARMACOLOGY Lactic acid is an alpha-hydroxy acid. It is a normal constituent of tissues and blood. The alpha-hydroxy acids (and their salts) are felt to act as humectants when applied to the skin. This property may influence hydration of the stratum corneum. In addition, lactic acid, when applied to the skin, may act to decrease corneocyte cohesion. The mechanism(s) by which this is accomplished is not yet known. An in vitro study of percutaneous absorption of ammonium lactate cream using human cadaver skin indicates that approximately 6.1% of the material was absorbed after 68 hours.
Source: RxNorm + openFDA + RxClass + FAERS · 2026
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