Transient neonatal diabetes mellitus

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Transient neonatal diabetes mellitus

ORPHA:99886Disease

Also called TNDM

What it is

Transient neonatal diabetes mellitus (TNDM) is a genetically heterogeneous form of neonatal diabetes (NDM) characterized by hyperglycemia presenting in the neonatal period that remits during infancy but recurs in later life in most patients.

Key facts

Prevalence
1-9 / 1 000 000 (at birth, Europe)
Age of onset
Antenatal, Neonatal
Inheritance
Autosomal dominant, Autosomal recessive, Not applicable
Classified as
Disease

Prevalence figures describe populations, not individuals, and are often estimates from a single study. Where the figure is an incidence or a birth prevalence, it says so.

Signs and symptoms

These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.

Genes

ABCC8Disease-causing germline mutation(s)
HYMAIDisease-causing germline mutation(s)
KCNJ11Disease-causing germline mutation(s)
PLAGL1Disease-causing germline mutation(s)
ZFP57Disease-causing germline mutation(s)

ICD-10 codes

P70.2filed under a broader ICD-10 category — shared with 5 other rare diseases

ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.

Related health topics

Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.

Cross-references

GARD 1839OMIM 601410OMIM 610374OMIM 610582UMLS C0342273

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.

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