Rare diseases · Sign or symptom
Upper limb hyperreflexia
HP:0007350
What it means
Increased intensity of the a reflex in the arm.
Rare diseases that can present with this20
Very common80–99%
5Common30–79%
8- Autosomal dominant spastic paraplegia type 10
- Autosomal dominant spastic paraplegia type 13
- Autosomal dominant spastic paraplegia type 31
- Autosomal dominant spastic paraplegia type 9B
- Autosomal recessive spastic paraplegia type 11
- Autosomal recessive spastic paraplegia type 76
- Early-onset cerebellar ataxia with retained tendon reflexes
- Isolated succinate-CoQ reductase deficiency
Sometimes5–29%
7- Autosomal dominant spastic paraplegia type 12
- Autosomal dominant spastic paraplegia type 19
- Autosomal dominant spastic paraplegia type 29
- Autosomal dominant spastic paraplegia type 37
- Autosomal dominant spastic paraplegia type 4
- Neuroferritinopathy
- Recessive intellectual disability-motor dysfunction-multiple joint contractures syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Hyperreflexia in upper limbs
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.