Rare diseases · Sign or symptom

Scrotal hyperpigmentation

HP:0012855

What it means

Increased pigmentation (skin color) of the scrotum.

This finding may be normal variation but can also be seen with congenital adrenal hyperplasia and other causes of excessive adrenocorticotrophic hormone (ACTH) stimulation.

Rare diseases that can present with this1

Sometimes5–29%

1

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Hyperpigmentation of the scrotum · Hyperpigmented scrotum · Increased pigmentation in scrotum

Scrotal hyperpigmentation

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.