Granular corneal dystrophy type II

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Granular corneal dystrophy type II

ORPHA:98963Disease

Also called Avellino corneal dystrophy · GCD2 · GCDII · Granular corneal dystrophy type 2 · Granular-lattice corneal dystrophy

What it is

Type II granular corneal dystrophy (GCDII) is a rare form of stromal corneal dystrophy characterized by irregular-shaped well-demarcated granular deposits in the superficial central corneal stroma, and progressive visual impairment.

Key facts

Age of onset
Childhood
Inheritance
Autosomal dominant
Classified as
Disease

Signs and symptoms

These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.

Gene

TGFBIDisease-causing germline mutation(s)

ICD-10 codes

H18.5filed under a broader ICD-10 category — shared with 25 other rare diseases

ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.

Related health topics

Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.

Cross-references

GARD 9278MESH C535474MONDO 0011855OMIM 607541UMLS C1275685

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.

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