Rare diseases · Sign or symptom

Oxygen desaturation on exertion

HP:0030874

What it means

Oxygen saturation less than 95% on exertion or arterial partial pressure of oxygen falling by more than 1kPa.

Rare diseases that can present with this2

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: O2 desaturation on exertion

Oxygen desaturation on exertion

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.