Rare diseases · Sign or symptom
Open bite
Absence of overlap of upper and lower teeth
HP:0010807
What it means
Visible space between the dental arches in occlusion.
An open bite produces an absence of vertical overlap of the two dental arches. It may be associated with malocclusion, but this should be coded separately. Open bite can be accompanied by malocclusion, which is a complex bundled term. The Angle classification of malocclusion (Classes I-III) is widely used in the orthodontics community [Moyers, [1973]] for the characterization of malocclusion.
Rare diseases that can present with this33
Very common80–99%
11- 49,XXXXY syndrome
- Autosomal dominant prognathism
- Autosomal recessive Robinow syndrome
- Camptodactyly syndrome, Guadalajara type 1
- Intellectual disability, Buenos-Aires type
- McDonough syndrome
- Microcephalic primordial dwarfism, Montreal type
- Proteus-like syndrome
- Treacher-Collins syndrome
- Williams syndrome
- X-linked intellectual disability, Cabezas type
Common30–79%
12- 48,XXXY syndrome
- 48,XXYY syndrome
- Alpha-mannosidosis
- Autosomal dominant Robinow syndrome
- Autosomal recessive faciodigitogenital syndrome
- Bencze syndrome
- Cleidocranial dysplasia
- Familial scaphocephaly syndrome, McGillivray type
- Grant syndrome
- Hajdu-Cheney syndrome
- Maxillonasal dysplasia
- Saethre-Chotzen syndrome
Sometimes5–29%
10- 17p11.2microduplication syndrome
- Acrodysostosis
- Hemifacial hyperplasia
- Hereditary acrokeratotic poikiloderma
- Marfan syndrome
- Neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-skeletal anomalies syndrome due to 9q21.3 microdeletion
- Neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-skeletal anomalies syndrome due to a point mutation
- Oculocerebrorenal syndrome of Lowe
and 2 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Open bite between upper and lower teeth
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.