Rare diseases · Sign or symptom

Multiple small medullary renal cysts

HP:0008659

What it means

The presence of many cysts in the medulla of the kidney.

This feature is the cardinal sign of medullary cystic disease, also known as medullary sponge disease.

Rare diseases that can present with this1

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Medullary cystic disease · Medullary sponge kidney disease

Multiple small medullary renal cysts

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.