Rare diseases · Sign or symptom
Metopic depression
Depression of frontal cranial suture
HP:0011223
What it means
Linear vertical groove in the midline of the forehead, extending from hairline to glabella.
Rare diseases that can present with this1
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Depression of metopic cranial suture · Frontal suture depression
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.