Rare diseases · Sign or symptom
Long palpebral fissure
Broad opening between the eyelids
HP:0000637
What it means
Distance between medial and lateral canthi is more than two standard deviations above the mean for age (objective); or, apparently increased length of the palpebral fissures.
Rare diseases that can present with this29
Very common80–99%
12- 8q12microduplication syndrome
- Autosomal recessive faciodigitogenital syndrome
- Baraitser-Winter cerebrofrontofacial syndrome
- Cardiofaciocutaneous syndrome
- Craniosynostosis, Philadelphia type
- Familial intestinal malrotation
- Neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-skeletal anomalies syndrome
- Neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-skeletal anomalies syndrome due to 9q21.3 microdeletion
- Neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-skeletal anomalies syndrome due to a point mutation
- Spondyloepiphyseal dysplasia-craniosynostosis-cleft palate-cataracts-intellectual disability syndrome
- Thakker-Donnai syndrome
- X small rings syndrome
Common30–79%
10- 9q21.13microdeletion syndrome
- Aphonia-deafness-retinal dystrophy-bifid halluces-intellectual disability syndrome
- Autosomal dominant Robinow syndrome
- Autosomal recessive Robinow syndrome
- Early-onset seizures-distal limb anomalies-facial dysmorphism-global developmental delay syndrome
- Hyperphosphatasia-intellectual disability syndrome
- Kabuki syndrome
- KBG syndrome
- Pontocerebellar hypoplasia type 10
- Roifman syndrome
Sometimes5–29%
6- Facial dysmorphism-developmental delay-behavioral abnormalities syndrome due to WAC point mutation
- PDE4D haploinsufficiency syndrome
- PURA-related severe neonatal hypotonia-seizures-encephalopathy syndrome due to a point mutation
- Severe intellectual disability-poor language-strabismus-grimacing face-long fingers syndrome
- Tall stature-intellectual disability-renal anomalies syndrome
- WAC-related facial dysmorphism-developmental delay-behavioral abnormalities syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Broad palpebral fissure · Long opening between the eyelids · Long palpebral fissures · Wide opening between the eyelids · Wide palpebral fissure · Wide palpebral fissures
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.