Rare diseases · Sign or symptom

Ineffective esophageal peristalsis

HP:0031857

What it means

Reduced or inadequate esophageal peristalsis, with resultant slow passage of contents through the esophagus.

Ineffective esophageal motility can be diagnosed by high-resolution manometry if 50% or more swallows are ineffective (failed or weak with the distal contractile integral less than 450 mmHg/s/cm).

Rare diseases that can present with this1

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Ineffective esophageal motility

Ineffective esophageal peristalsis

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.