Rare diseases · Sign or symptom
Horizontal nystagmus
HP:0000666
What it means
Nystagmus consisting of horizontal to-and-fro eye movements.
Rare diseases that can present with this30
Common30–79%
12- Autosomal recessive cerebellar ataxia due to CWF19L1 deficiency
- Autosomal recessive cerebellar ataxia-pyramidal signs-nystagmus-oculomotor apraxia syndrome
- Autosomal recessive congenital cerebellar ataxia due to GRID2 deficiency
- Autosomal recessive spastic ataxia with leukoencephalopathy
- Autosomal recessive spastic paraplegia type 78
- Autosomal spastic paraplegia type 58
- Childhood-onset autosomal recessive slowly progressive spinocerebellar ataxia
- Fatty acid hydroxylase-associated neurodegeneration
- Focal facial dermal dysplasia type II
- Miller Fisher syndrome
- Rolandic epilepsy-paroxysmal exercise-induced dystonia-writer's cramp syndrome
- Spinocerebellar ataxia type 37
Sometimes5–29%
16- 14q11.2microduplication syndrome
- 19p13.3microduplication syndrome
- Adult-onset autosomal recessive cerebellar ataxia
- Autosomal dominant dopa-responsive dystonia
- Autosomal dominant primary microcephaly
- Autosomal dominant spastic paraplegia type 9A
- Autosomal recessive cerebellar ataxia due to STUB1 deficiency
- Autosomal spastic paraplegia type 18
and 8 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Nystagmus, horizontal
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.