Rare diseases · Sign or symptom
High forehead
HP:0000348
What it means
An abnormally increased height of the forehead.
Rare diseases that can present with this126
Very common80–99%
51- 14q22q23microdeletion syndrome
- 16q24.3microdeletion syndrome
- 17p13.3microduplication syndrome
- 20q11.2microdeletion syndrome
- 5q14.3microdeletion syndrome
- Acrofacial dysostosis, Catania type
- Beta-mercaptolactate cysteine disulfiduria
- Branchioskeletogenital syndrome
- Camptodactyly-joint contractures-facial skeletal defects syndrome
- Corpus callosum agenesis-intellectual disability-coloboma-micrognathia syndrome
- Craniosynostosis-hydrocephalus-Arnold-Chiari malformation type I-radioulnar synostosis syndrome
- Crouzon syndrome
- Crouzon syndrome-acanthosis nigricans syndrome
- Developmental malformations-deafness-dystonia syndrome
- Distal Xq28 microduplication syndrome
- Emery-Nelson syndrome
- Facial dysmorphism-macrocephaly-myopia-Dandy-Walker malformation syndrome
- Familial intestinal malrotation
- Familial scaphocephaly syndrome, McGillivray type
- Flat face-microstomia-ear anomaly syndrome
- GAPO syndrome
- German syndrome
- Intellectual disability-balding-patella luxation-acromicria syndrome
- Intellectual disability-seizures-hypophosphatasia-ophthalmic-skeletal anomalies syndrome
- Koolen-De Vries syndrome
- Laron syndrome
- Lujan-Fryns syndrome
- Metatropic dysplasia
- Miller-Dieker syndrome
- Neonatal adrenoleukodystrophy
- Non-distal duplication 10q syndrome
- Noonan syndrome
- Osteosclerosis-developmental delay-craniosynostosis syndrome
- Paternal 20q13.2q13.3 microdeletion syndrome
- Perlman syndrome
- Pfeiffer syndrome type 1
- Pfeiffer syndrome type 2
- Pfeiffer syndrome type 3
- Ring chromosome 8 syndrome
- Saethre-Chotzen syndrome
- Sanjad-Sakati syndrome
- SIX2-related frontonasal dysplasia
- Stormorken-Sjaastad-Langslet syndrome
- THOC6-related developmental delay-microcephaly-facial dysmorphism syndrome
- Trisomy 8q syndrome
- Williams syndrome
- Wolf-Hirschhorn syndrome
- X-linked intellectual disability-hypotonia-facial dysmorphism-aggressive behavior syndrome
- X-linked intellectual disability, Shrimpton type
- Zellweger-like syndrome without peroxisomal anomalies
- Zellweger syndrome
Common30–79%
29- 19q13.11microdeletion syndrome
- 22q11.2duplication syndrome
- 2q32q33deletion syndrome
- 5q22microdeletion syndrome
- 8p23.1microdeletion syndrome
- 8q21.11microdeletion syndrome
- Acrocardiofacial syndrome
- Alpha-thalassemia-intellectual disability syndrome linked to chromosome 16
- Aneurysm-osteoarthritis syndrome
- Aymé-Gripp syndrome
- Basel-Vanagaite-Smirin-Yosef syndrome
- Brachymorphism-onychodysplasia-dysphalangism syndrome
- Cardiofaciocutaneous syndrome
- Combined immunodeficiency with facio-oculo-skeletal anomalies
- Deaf blind hypopigmentation syndrome, Yemenite type
- FG syndrome type 1
- Frank-Ter Haar syndrome
- Greig cephalopolysyndactyly syndrome
- Hydrocephalus-costovertebral dysplasia-Sprengel anomaly syndrome
- Isolated sedoheptulokinase deficiency
- Jacobsen syndrome
- Macrocephaly-spastic paraplegia-dysmorphism syndrome
- Malan overgrowth syndrome
- Megalencephaly-capillary malformation-polymicrogyria syndrome
- Megalencephaly-polymicrogyria-postaxial polydactyly-hydrocephalus syndrome
- Micrognathia-recurrent infections-behavioral abnormalities-mild intellectual disability syndrome
- Mietens syndrome
- MOMO syndrome
- Monosomy 22 syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Tall forehead
High forehead
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.