Rare diseases · Sign or symptom
EEG with generalized epileptiform discharges
HP:0011198
What it means
EEG discharges recorded on the entire scalp typically seen in persons with epilepsy.
Spikes (<70 ms) and sharp waves (70-200 ms) are sharp transient waves that have a strong association with epilepsy. No difference is noted in terms of clinical significance of spikes and sharp waves. Significant spikes usually are followed by a slow wave.
Rare diseases that can present with this11
Common30–79%
6Sometimes5–29%
5- Dravet syndrome
- Global developmental delay-neuro-ophthalmological abnormalities-seizures-intellectual disability syndrome
- New-onset refractory status epilepticus
- Pyridoxine-dependent-developmental and epileptic encephalopathy
- TBCK-related encephalopathy-severe hypotonia-craniofacial dysmorphism syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: EEG with generalised epileptiform discharges
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.