Rare diseases · Sign or symptom
Distal upper limb muscle weakness
HP:0008959
What it means
Reduced strength of the distal musculature of the arms.
Rare diseases that can present with this23
Very common80–99%
5Common30–79%
7- Adenylosuccinate synthetase-like 1-related distal myopathy
- Autosomal dominant Charcot-Marie-Tooth disease type 2Y
- Charcot-Marie-Tooth disease-deafness-intellectual disability syndrome
- Charcot-Marie-Tooth disease type 2B1
- Charcot-Marie-Tooth disease type 4G
- Facioscapulohumeral dystrophy
- Moderate multiminicore disease with hand involvement
Sometimes5–29%
9- Autosomal dominant Charcot-Marie-Tooth disease type 2Z
- Charcot-Marie-Tooth disease type 4D
- Familial or sporadic hemiplegic migraine
- FLNC-related handgrip and calf weakness-distal myopathy
- GMPPB-related limb-girdle muscular dystrophy R19
- Japanese encephalitis
- Oculopharyngodistal myopathy
- Proximal spinal muscular atrophy
and 1 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.