Rare diseases · Sign or symptom
Distal sensory impairment
Decreased sensation in extremities
HP:0002936
What it means
An abnormal reduction in sensation in the distal portions of the extremities.
Rare diseases that can present with this41
Very common80–99%
9- Adrenomyeloneuropathy
- Autosomal recessive Charcot-Marie-Tooth disease with hoarseness
- Charcot-Marie-Tooth disease type 1E
- Charcot-Marie-Tooth disease type 2B1
- Charcot-Marie-Tooth disease type 4A
- Charcot-Marie-Tooth disease type 4G
- Hereditary sensory and autonomic neuropathy type 1
- KLHL9-related early-onset distal myopathy
- X-linked Charcot-Marie-Tooth disease type 6
Common30–79%
20- Adult-onset autosomal dominant leukodystrophy
- Adult polyglucosan body disease
- Autosomal dominant Charcot-Marie-Tooth disease type 2A2
- Autosomal dominant Charcot-Marie-Tooth disease type 2K
- Autosomal dominant Charcot-Marie-Tooth disease type 2Y
- Autosomal dominant spastic paraplegia type 10
- Autosomal dominant spastic paraplegia type 31
- Autosomal recessive spastic paraplegia type 55
- Autosomal spastic paraplegia type 30
- Charcot-Marie-Tooth disease type 1A
- Charcot-Marie-Tooth disease type 4B2
- Combined oxidative phosphorylation defect type 7
- Giant axonal neuropathy
- Hereditary motor and sensory neuropathy, Okinawa type
- HNRNPA1-related adult-onset distal myopathy
- PMP22-RAI1 contiguous gene duplication syndrome
- Polyneuropathy associated with IgM monoclonal gammopathy
- Spinocerebellar ataxia type 25
- Spinocerebellar ataxia type 43
- X-linked Charcot-Marie-Tooth disease type 2
Sometimes5–29%
11- Autosomal dominant spastic paraplegia type 17
- Autosomal recessive progressive external ophthalmoplegia
- Charcot-Marie-Tooth disease type 4D
- Hereditary sensory and autonomic neuropathy type 4
- Hyperprolinemia type 2
- Isaacs syndrome
- Parkes Weber syndrome
- Primary erythromelalgia
and 3 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Decreased distal sensation · Distal sensation loss · Distal sensory impairment in lower limbs · Distal sensory impairment of the lower extremities · Distal sensory loss · Distal sensory loss, upper and lower limbs · Loss of distal sensation
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.