Rare diseases · Sign or symptom

Diminishment of social interactions

HP:5200310

What it means

A reduction in the tendency of a person to seek or maintain social connections or interactions with others compared to previous norms for an individual.

This feature may be reported by family members or peers. This feature is distinct from (but may be accompanied by) loneliness, which can be defined as a perceived discrepancy between one's actual and desired social relationships.

Rare diseases that can present with this1

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Reduced, declined or lessened social interactions

Diminishment of social interactions

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.