Rare diseases · Sign or symptom

Diastolic heart murmur

HP:0031668

What it means

A heart murmur that occurs during diastole, i.e., in the time between S2 and the subsequent S1.

Diastolic murmurs always signify structural heart disease.

Rare diseases that can present with this2

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Diastolic heart murmur

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.