Rare diseases · Sign or symptom
Decreased circulating LDL-C concentration
HP:0003563
What it means
The concentration of low-density lipoprotein cholesterol in the blood circulation is below the lower limit of normal.
Beta-lipoprotein cholesterol is a synonym for low-density lipoprotein (LDL) cholesterol.
Rare diseases that can present with this5
Common30–79%
4The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Decreased circulating low-density lipoprotein levels · Decreased LDL · Decreased LDLc concentration · Decreased low-density lipoprotein cholesterol concentration · Decreased low-density lipoprotein cholesterol level · Decreased low-density lipoprotein cholesterol level in blood · Hypobetalipoproteinemia · Reduced low-density lipoprotein cholesterol concentration
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.