Rare diseases · Sign or symptom
Decreased circulating HDL-C concentration
Decreased circulating high-density lipoprotein cholesterol
HP:0003233
What it means
The concentration of high-density lipoprotein cholesterol in the blood circulation is below the lower limit of normal.
Rare diseases that can present with this18
Very common80–99%
4Common30–79%
5Sometimes5–29%
8The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Decreased circulating high-density lipoprotein levels · Decreased HDL cholesterol · Decreased high-density lipoprotein cholesterol concentration · Decreased high-density lipoprotein cholesterol level · Decreased high-density lipoprotein cholesterol level in blood · Hypoalphalipoproteinemia · Low HDL-cholesterol · Reduced high-density lipoprotein cholesterol concentration
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.