Rare diseases · Sign or symptom
Coronary artery atherosclerosis
Plaque build-up in arteries supplying blood to heart
HP:0001677
What it means
Reduction of the diameter of the coronary arteries as the result of an accumulation of atheromatous plaques within the walls of the coronary arteries, which increases the risk of myocardial ischemia.
Coronary artery disease, also called atherosclerotic heart disease, is the result of atheromatous plaques within the coronary arteries leading to myocardial ischemia and infarction.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this21
Very common80–99%
3Common30–79%
8- Coarctation of aorta
- Estrogen resistance syndrome
- Familial aortic dissection
- Familial thoracic aortic aneurysm and aortic dissection
- Homozygous familial hypercholesterolemia
- Hypercholesterolemia due to cholesterol 7alpha-hydroxylase deficiency
- Lysosomal acid lipase deficiency
- Primary triglyceride deposit cardiomyovasculopathy
Sometimes5–29%
8- AApoAIV amyloidosis
- Autosomal semi-dominant severe lipodystrophic laminopathy
- Familial partial lipodystrophy, Dunnigan type
- Familial partial lipodystrophy, Köbberling type
- Gastrocutaneous syndrome
- Moyamoya angiopathy-short stature-facial dysmorphism-hypergonadotropic hypogonadism syndrome
- PPARG-related familial partial lipodystrophy
- Proximal 3p25.3 microdeletion syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Coronary atherosclerosis · Coronary disease
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.