Rare diseases · Sign or symptom
Conductive hearing impairment
Conductive deafness
HP:0000405
What it means
An abnormality of vibrational conductance of sound to the inner ear leading to impairment of sensory perception of sound.
A conductive hearing impariment with greater than 90 dB loss.
Rare diseases that can present with this122
Very common80–99%
25- 22q11.2deletion syndrome
- Ankyloblepharon-ectodermal defects-cleft lip/palate syndrome
- Apert syndrome
- Branchiogenic deafness syndrome
- Branchio-oculo-facial syndrome
- Cardiospondylocarpofacial syndrome
- Conductive deafness-malformed external ear syndrome
- Conductive deafness-ptosis-skeletal anomalies syndrome
- Cooper-Jabs syndrome
- Cutaneous mastocytosis-deafness-microtia syndrome
- Deafness-ear malformation-facial palsy syndrome
- Deafness-hypogonadism syndrome
- Distal deletion 19p syndrome
- Gorlin-Chaudhry-Moss syndrome
- Hutchinson-Gilford progeria syndrome
- Intellectual disability-cataracts-calcified pinnae-myopathy syndrome
- Intellectual disability-polydactyly-uncombable hair syndrome
- Johnson neuroectodermal syndrome
- Lateral meningocele syndrome
- Metaphyseal dysostosis-intellectual disability-conductive deafness syndrome
- Multiple synostoses syndrome
- Orofaciodigital syndrome type 4
- Otofaciocervical syndrome
- Retinitis pigmentosa
- X-linked mandibulofacial dysostosis
Common30–79%
38- Acrocraniofacial dysostosis
- Acrootoocular syndrome
- Acro-renal-ocular syndrome
- Arginine vasopressin resistance-intracranial calcification-short stature-facial dysmorphism syndrome
- Blepharo-cheilo-odontic syndrome
- BOR syndrome
- Branchiootic syndrome
- Brittle cornea syndrome
- Cerebrocostomandibular syndrome
- Cerebrofacioarticular syndrome
- Cornelia de Lange syndrome
- Craniodiaphyseal dysplasia
- Crouzon syndrome
- Crouzon syndrome-acanthosis nigricans syndrome
- Distal limb deficiencies-micrognathia syndrome
- Frontometaphyseal dysplasia
- Frontonasal dysplasia-severe microphthalmia-severe facial clefting syndrome
- Geleophysic dysplasia
- Hypertelorism-microtia-facial clefting syndrome
- Kabuki syndrome
- Marshall-Smith syndrome
- Mucolipidosis type II
- Mucolipidosis type III alpha/beta
- Mucopolysaccharidosis type 2
- Multiple pterygium-malignant hyperthermia syndrome
- Nephrosis-deafness-urinary tract-digital malformations syndrome
- Oculoauriculofrontonasal syndrome
- Oculodentodigital dysplasia
- Orofaciodigital syndrome type 6
- Osteopathia striata-cranial sclerosis syndrome
- PHAVER syndrome
- Postaxial acrofacial dysostosis
- Smith-Magenis syndrome
- Thoracic dysplasia-hydrocephalus syndrome
- Treacher-Collins syndrome
- Trisomy 8p syndrome
- Xq21microdeletion syndrome
- Zechi-Ceide syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Conduction deafness · Conductive hearing loss · Hearing loss, conductive
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.