Rare diseases · Sign or symptom

Cloverleaf skull

HP:0002676

What it means

Trilobar skull configuration when viewed from the front or behind.

A deformity of the skull that resembles a cloverleaf and is characterized by very prominent temporal bones with constriction of the remainder of the cranium. Cloverleaf skull is commonly accompanied by hydrocephalus. See figure 3 in PMID:29089832.

Rare diseases that can present with this10

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Cloverleaf cranium shape · Cloverleaf skull shape · Kleeblattschaedel · Trilobar cranium shape · Trilobar skull shape

Cloverleaf skull

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.