Rare diseases · Sign or symptom
Cloverleaf skull
HP:0002676
What it means
Trilobar skull configuration when viewed from the front or behind.
A deformity of the skull that resembles a cloverleaf and is characterized by very prominent temporal bones with constriction of the remainder of the cranium. Cloverleaf skull is commonly accompanied by hydrocephalus. See figure 3 in PMID:29089832.
Rare diseases that can present with this10
Very common80–99%
5The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Cloverleaf cranium shape · Cloverleaf skull shape · Kleeblattschaedel · Trilobar cranium shape · Trilobar skull shape
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.