Rare diseases · Sign or symptom
Chronic kidney disease
HP:0012622
What it means
Functional anomaly of the kidney persisting for at least three months.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this51
Common30–79%
30- AA amyloidosis
- AApoAIV amyloidosis
- Adenine phosphoribosyltransferase deficiency
- Alström syndrome
- Autosomal dominant Alport syndrome
- Autosomal dominant polycystic kidney disease
- Bardet-Biedl syndrome
- Bartter syndrome type 4
- C3 glomerulopathy
- Distal 16p11.2 microdeletion syndrome
- Hereditary steroid-resistant nephrotic syndrome
- Hypertrophic cardiomyopathy with kidney anomalies due to mitochondrial DNA mutation
- Idiopathic steroid-sensitive nephrotic syndrome with secondary steroid resistance
- IgG4-related kidney disease
- Lysinuric protein intolerance
- Microcephaly-glomerulonephritis-marfanoid habitus syndrome
- Paroxysmal nocturnal hemoglobinuria
- Primary Fanconi renotubular syndrome
- Primary hyperoxaluria
- Primary membranoproliferative glomerulonephritis
- Renal dysplasia
- Renal hypoplasia
- Renal hypoplasia, bilateral
- Senior-Boichis syndrome
- Severe growth deficiency-strabismus-extensive dermal melanocytosis-intellectual disability syndrome
- Sickle cell anemia
- Spondyloenchondrodysplasia
- Tuberous sclerosis complex
- Variant ABeta2M amyloidosis
- X-linked Alport syndrome-diffuse leiomyomatosis
Sometimes5–29%
10- Autosomal recessive generalized dystrophic epidermolysis bullosa, severe form
- Glycogen storage disease due to lactate dehydrogenase M-subunit deficiency
- HANAC syndrome
- Hereditary fructose intolerance
- Hereditary renal hypouricemia
- Hereditary xanthinuria
- Juvenile nephropathic cystinosis
- Kearns-Sayre syndrome
and 2 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: CKD · Loss of renal function · Progressive renal failure · Progressive renal insufficiency · Renal failure, progressive · Renal insufficiency, progressive
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.