Rare diseases · Sign or symptom
Cerebral calcification
Abnormal deposits of calcium in the brain
HP:0002514
What it means
The presence of calcium deposition within the cerebrum.
This finding can be demonstrated upon cerebral computer tomography, magnetic resonance imaging, or potentially by standard radiography of the skull. The cerebrum is the largest of the five major components of the brain, which comprise the cerebrum, cerebellum, brain stem, pituitary gland, and hypothalamus.
Rare diseases that can present with this65
Very common80–99%
15- Arginine vasopressin resistance-intracranial calcification-short stature-facial dysmorphism syndrome
- Bonnemann-Meinecke-Reich syndrome
- COFS syndrome
- Craniofacial dysostosis-diaphyseal hyperplasia syndrome
- Craniopharyngioma
- Dysosteosclerosis
- Fried syndrome
- Gorlin syndrome
- Infantile choroidocerebral calcification syndrome
- Leukoencephalopathy with calcifications and cysts
- Mitochondrial DNA depletion syndrome, encephalomyopathic form with methylmalonic aciduria
- Occipital horn syndrome
- Pseudo-TORCH syndrome type 1
- Symmetrical thalamic calcifications
- Visceral neuropathy-brain anomalies-facial dysmorphism-developmental delay syndrome
Common30–79%
17- ABeta amyloidosis, Dutch type
- Aicardi-Goutières syndrome
- Alexander disease
- Carnitine palmitoyl transferase II deficiency, neonatal form
- Central neurocytoma
- Cockayne syndrome
- Cysticercosis
- Encephalocraniocutaneous lipomatosis
- Familial isolated hypoparathyroidism
- Lathosterolosis
- Marshall syndrome
- Nasu-Hakola disease
- Oculodentodigital dysplasia
- Osteopetrosis with renal tubular acidosis
- Papillon-Lefèvre syndrome
- Phakomatosis pigmentovascularis
- Spinocerebellar ataxia type 20
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.