Rare diseases · Sign or symptom
Calf muscle hypertrophy
Increased size of calf muscles
HP:0008981
What it means
Muscle hypertrophy affecting the calf muscles.
Distal lower limb hypertrophy
Rare diseases that can present with this27
Very common80–99%
4Common30–79%
11- Alpha-dystroglycan-related limb-girdle muscular dystrophy R16
- Beta-sarcoglycan-related limb-girdle muscular dystrophy R4
- Calpain-3-related limb-girdle muscular dystrophy R1
- Congenital muscular dystrophy with intellectual disability
- DPM3-CDG
- FKRP-related limb-girdle muscular dystrophy R9
- Gamma-sarcoglycan-related limb-girdle muscular dystrophy R5
- Isaacs syndrome
- POMGNT2-related limb-girdle muscular dystrophy R24
- POMT1-related limb-girdle muscular dystrophy R11
- Xp21deletion syndrome
Sometimes5–29%
12- Anoctamin-5-related limb-girdle muscular dystrophy R12
- Autosomal dominant adult-onset proximal spinal muscular atrophy
- Autosomal dominant centronuclear myopathy
- Charcot-Marie-Tooth disease type 1A
- Dysferlin-related limb-girdle muscular dystrophy R2
- Episodic ataxia type 1
- Hereditary myopathy with early respiratory failure
- Miyoshi myopathy
and 4 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Calf hypertrophy · Muscular hypertrophy of the calf muscles
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.