Rare diseases · Sign or symptom
Blepharospasm
Eyelid spasm
HP:0000643
What it means
A focal dystonia that affects the muscles of the eyelids and brow, associated with involuntary recurrent spasm of both eyelids.
Rare diseases that can present with this27
Common30–79%
13- Atypical progressive supranuclear palsy syndrome
- Classic progressive supranuclear palsy syndrome
- Congenital glaucoma
- Cranio-cervical dystonia with laryngeal and upper-limb involvement
- Gelatinous drop-like corneal dystrophy
- Limbal stem cell deficiency
- Primary dystonia, DYT21 type
- Primary dystonia, DYT2 type
- Progressive supranuclear palsy
- Saethre-Chotzen syndrome
- Spinocerebellar ataxia type 17
- Vernal keratoconjunctivitis
- X-linked dystonia-parkinsonism
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Eyelid twitching · Involuntary closure of eyelid · Spontaneous closure of eyelid
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.