Anti-histidyl tRNA synthetase antibody positivity

What it means

The presence of autoantibodies (immunoglobulins) in the blood circulation that react against histidyl tRNA synthetase.

Histidyl-tRNA synthetase (HRS = Jo-1) represents a key autoantibody target in the anti-synthetase syndrome that is marked by myositis as well as extra-muscular organ complications including interstitial lung disease (ILD).

Rare diseases that can present with this3

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Anti-Jo-1 antibody positivity · Anti-JO1 antibody positivity