Rare diseases · Sign or symptom
Ankyloglossia
Tongue tied
HP:0010296
What it means
Short or anteriorly attached lingual frenulum, associated with limited mobility of the tongue.
The anterior third of the tongue is usually free or is partially attached to the floor of the mouth by the lingual frenulum. There is a spectrum ranging from fusion of the tongue to the floor of the mouth (ankyloglossia inferiorum) to a lingual frenulum that is short or anchored toward the tip of the tongue (sometimes called tongue tie). Ankyloglossia may be associated with a mild indentation of the tip of the tongue, which should not be coded as a Bifid tongue.
Rare diseases that can present with this11
Common30–79%
3Sometimes5–29%
7- 1q21.1microdeletion syndrome
- Autosomal recessive generalized dystrophic epidermolysis bullosa, intermediate form
- Autosomal recessive generalized dystrophic epidermolysis bullosa, severe form
- Distal 22q11.2 microdeletion syndrome
- Robinow syndrome
- TELO2-related intellectual disability-neurodevelopmental disorder
- Van der Woude syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Tongue tie
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.