Rare diseases · Sign or symptom

Anisocoria

Asymmetric pupil sizes

HP:0009916

What it means

Anisocoria, or unequal pupil size, may represent a benign physiologic variant or a manifestation of disease.

Pathologic anisocoria can reflect an abnormality of the musculature of the iris or of the sympathetic or prasympathetic innervation of the iris.

Rare diseases that can present with this10

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Asymmetry of the pupils · Unequal pupil dilatation · Unequal pupil size

Anisocoria

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.