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Rare diseases · Sign or symptom

Abnormal HLA-DR+ T cell proportion

HP:5200023

What it means

The proportion of peripheral blood T lymphocytes expressing HLA-DR (CD3+HLA-DR+) is outside of the reference limit for age.

HLA-DR expression on T cells is an activation marker; elevated proportions reflect in vivo T cell activation status even when measured ex vivo without prior stimulation. This feature can be measured by flow cytometry.

Part of the broader category

Abnormal T cell subset number

Also called: Abnormal HLA-DR expression on T cells · Abnormal proportion of DR+ T cells

Abnormal HLA-DR+ T cell proportion

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.