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Start free with EleplanNeonatal hypoxic and ischemic brain injury
ORPHA:137577Particular clinical situation in a disease or syndrome
Also called HIE · Hypoxic and ischemic brain injury in the newborn · Hypoxic-ischemic encephalopathy · Perinatal hypoxia
What it is
A rare neonatal encephalopathy characterized by alterations in mental status ranging from irritability and decreased responsiveness to coma, as well as abnormal primitive reflexes, hypotonia, seizures, and abnormalities in feeding and respiration, with an onset within the first hours of life. The condition is associated with high mortality. Long-term sequelae include a spectrum of signs and symptoms including behavioral deficits, developmental delay, learning disabilities, cognitive impairment, seizures, visual and auditory dysfunction, and cerebral palsy.
Key facts
- Prevalence
- 1-9 / 100 000 (Europe)
- Age of onset
- Infancy, Neonatal
- Inheritance
- Not applicable
- Classified as
- Particular clinical situation in a disease or syndrome
Prevalence figures describe populations, not individuals, and are often estimates from a single study. Where the figure is an incidence or a birth prevalence, it says so.
ICD-10 codes
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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