Melanoma of soft tissue

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Melanoma of soft tissue

ORPHA:97338Disease

Also called Clear cell sarcoma of the tendons and aponeuroses

What it is

A rare soft tissue tumor characterized by a slowly growing mass typically involving tendons and aponeuroses of the extremities, composed of polygonal or spindle-shaped cells with melanocytic differentiation. The tumor typically affects young adults, who often present with pain or tenderness at the tumor site. Prognosis is poor with high recurrence rates and frequent metastasis, especially to lymph nodes, lung, and bones.

Key facts

Prevalence
1-9 / 100 000
Age of onset
Adult
Inheritance
Not applicable
Classified as
Disease

Prevalence figures describe populations, not individuals, and are often estimates from a single study. Where the figure is an incidence or a birth prevalence, it says so.

Genes

ATF1Part of a fusion gene
CREB1Part of a fusion gene
EWSR1Part of a fusion gene

ICD-10 codes

C43.6ICD-10 uses a narrower term — shared with 1 other rare disease
C43.7ICD-10 uses a narrower term — shared with 1 other rare disease

ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.

Related health topics

Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.

Cross-references

MONDO 0019971UMLS C0206651

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.

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