Isolated congenital breast…

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Isolated congenital breast hypoplasia/aplasia

ORPHA:180188Morphological anomaly

Also called Isolated congenital amastia

What it is

A rare breast malformation characterized by congenital absence of breast and nipple (amastia), or nipple or mammary gland (athelia or amazia, respectively). It can be unilateral or bilateral and may occur as an isolated malformation or be associated with a syndrome or cluster of other anomalies.

Key facts

Inheritance
Autosomal recessive
Classified as
Morphological anomaly

Gene

PTPRFDisease-causing germline mutation(s) (loss of function)

ICD-10 codes

Q83.0ICD-10 names this disease exactly

Cross-references

GARD 9489MESH C562989MONDO 0015855OMIM 113700OMIM 616001UMLS C0432357

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.

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