sparsentan 400 MG Oral Tablet
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sparsentan 400 MG Oral Tablet
400 MG · Oral Tablet · oral
A form of sparsentan →
sparsentan 400 MG Oral Tablet — Other agents acting on the renin-angiotensin system. Strength, form, class, interactions & more.
Active ingredient
Classification
Other agents acting on the renin-angiotensin systemAngiotensin 2 Receptor Blocker
Drug interactions
Sparsentan has several drug interactions that may affect its exposure and efficacy, as well as the risk of adverse effects.
- majorstrong CYP3A inhibitors — Increased sparsentan exposure
- moderatemoderate CYP3A inhibitors — Increased sparsentan exposure
- majorstrong CYP3A inducers — Decreased sparsentan exposure
- moderateNSAIDs — Increased risk of kidney injury
- moderateCYP2B6, 2C9, and 2C19 substrates — Decreased exposure of these substrates
- moderateP-gp substrates — Increased exposure to substrates
- majoragents increasing serum potassium — Increased risk of hyperkalemia
- majorARBs, ERAs, or aliskiren — Increased risks of hypotension, syncope, hyperkalemia, and changes in renal function
Source: RxNorm + openFDA + RxClass + FAERS · 2026
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