sapropterin dihydrochloride 100 MG Oral Tablet [Kuvan]

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Clinical drug

sapropterin dihydrochloride 100 MG Oral Tablet [Kuvan]

100 MG · Oral Tablet · oral

A form of sapropterin dihydrochloride →

sapropterin dihydrochloride 100 MG Oral Tablet [Kuvan] — Various alimentary tract and metabolism products. Strength, form, class, interactions & more.

sapropterin dihydrochloride 100 MG Oral Tablet [Kuvan]

Active ingredient

sapropterin dihydrochloride →

Classification

Various alimentary tract and metabolism productsPhenylalanine Hydroxylase Activator

Drug interactions

Sapropterin dihydrochloride has several clinically important drug interactions that may affect its efficacy and safety.

  • moderatelevodopa — may increase the availability of tyrosine, a precursor of levodopa
  • moderateinhibitors of folate synthesis (e.g., methotrexate, valproic acid, phenobarbital, trimethoprim) — may decrease the bioavailability of endogenous BH4, potentially increasing Phe levels
  • moderatePDE-5 inhibitors (e.g., sildenafil, vardenafil, tadalafil) — potential reduction in blood pressure due to combined vasorelaxation effects

Source: RxNorm + openFDA + RxClass + FAERS · 2026

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