prilocaine hydrochloride 40 MG/ML Injectable Solution
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prilocaine hydrochloride 40 MG/ML Injectable Solution
40 MG/ML · Injectable Solution · injection
A form of prilocaine →
prilocaine hydrochloride 40 MG/ML Injectable Solution — Amides. Strength, form, class, interactions & more.
Active ingredient
Classification
AmidesAmide Local Anesthetic
Drug interactions
Prilocaine has several drug interactions that may increase the risk of adverse effects, particularly methemoglobinemia.
- majorClass I antiarrhythmic drugs (tocainide, mexiletine) — toxic effects are additive and potentially synergistic
- majornitrates/nitrites (nitric oxide, nitroglycerin, nitroprusside, nitrous oxide) — increased risk of developing methemoglobinemia
- majorlocal anesthetics (articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, procaine, ropivacaine, tetracaine) — increased risk of developing methemoglobinemia
- majorantineoplastic agents (cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase) — increased risk of developing methemoglobinemia
- majorantibiotics (dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides) — increased risk of developing methemoglobinemia
- majorantimalarials (chloroquine, primaquine) — increased risk of developing methemoglobinemia
- majoranticonvulsants (phenobarbital, phenytoin, sodium valproate) — increased risk of developing methemoglobinemia
- majorother drugs (acetaminophen, metoclopramide, quinine, sulfasalazine) — increased risk of developing methemoglobinemia
- moderateClass III antiarrhythmic drugs (amiodarone, bretylium, sotalol, dofetilide) — caution is advised due to lack of specific interaction studies
Source: RxNorm + openFDA + RxClass + FAERS · 2026
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