povidone 0.005 MG/MG Ophthalmic Gel [iVizia]

Drug interactions

The label outlines several drug interactions associated with Bupivacaine Hydrochloride Injection and corticosteroids.

• majorlocal anesthetics — toxic effects are additive
• majornitrates — increased risk of developing methemoglobinemia
• majornitrites — increased risk of developing methemoglobinemia
• majorantineoplastic agents — increased risk of developing methemoglobinemia
• majorantibiotics — increased risk of developing methemoglobinemia
• majorantimalarials — increased risk of developing methemoglobinemia
• majoranticonvulsants — increased risk of developing methemoglobinemia
• unknownamphotericin B — risk of hypokalemia when used with corticosteroids
• unknownpotassium-depleting agents — risk of hypokalemia when used with corticosteroids
• moderatewarfarin — inhibition of response to warfarin
• moderateantidiabetic agents — dosage adjustments may be required due to increased blood glucose concentrations
• moderateisoniazid — serum concentrations may be decreased
• moderateCYP3A4 inhibitors — increased plasma concentration of triamcinolone leading to adverse reactions
• majordigitalis glycosides — increased risk of arrhythmias due to hypokalemia
• moderateestrogens — may increase the effect of certain corticosteroids
• moderatehepatic enzyme inducers — may enhance the metabolism of corticosteroids
• moderateNSAIDs — increased risk of gastrointestinal side effects
• moderatevaccines — diminished response to toxoids and live or inactivated vaccines