mefenamic acid 500 MG Oral Tablet
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mefenamic acid 500 MG Oral Tablet
500 MG · Oral Tablet · oral
A form of mefenamic acid →
mefenamic acid 500 MG Oral Tablet — Fenamates. Strength, form, class, interactions & more.
Active ingredient
Classification
FenamatesNonsteroidal Anti-inflammatory Drug
Drug interactions
Mefenamic acid has several clinically significant drug interactions that may increase the risk of adverse effects, particularly related to bleeding and renal function.
- majorwarfarin — increased risk of serious bleeding
- majoraspirin — increased risk of bleeding and GI adverse reactions
- moderateACE inhibitors — diminished antihypertensive effect
- moderateARBs — diminished antihypertensive effect
- moderatebeta-blockers — diminished antihypertensive effect
- moderateloop diuretics — reduced natriuretic effect
- moderatethiazide diuretics — reduced natriuretic effect
- moderatedigoxin — increased serum concentration and prolonged half-life
- moderatelithium — elevated plasma lithium levels and reduced renal clearance
- majormethotrexate — increased risk for methotrexate toxicity
- moderatecyclosporine — increased nephrotoxicity
- majorother NSAIDs or salicylates — increased risk of GI toxicity
- majorpemetrexed — increased risk of myelosuppression, renal, and GI toxicity
Source: RxNorm + openFDA + RxClass + FAERS · 2026
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