divalproex sodium 250 MG Delayed Release Oral Tablet [Depakote]

Drug interactions

Divalproex has several drug interactions that can affect its clearance and the pharmacokinetics of co-administered medications.

• majorphenytoin — increased valproate clearance
• majorcarbamazepine — increased valproate clearance
• majorphenobarbital — increased valproate clearance
• majorprimidone — increased valproate clearance
• majorrifampin — increased valproate clearance
• moderatefelbamate — increased valproate peak concentration
• moderateaspirin — increased free fraction of valproate
• majorcarbapenem antibiotics — reduction in serum valproic acid concentration
• majorestrogen-containing hormonal contraceptives — decreased concentration of valproate
• moderatemethotrexate — decreased serum valproate levels
• moderatewarfarin — dosage adjustment may be necessary
• moderatezidovudine — dosage adjustment may be necessary
• unknowntopiramate — hyperammonemia and encephalopathy
• moderatecannabidiol — ALT and/or AST elevation
• moderateamitriptyline/nortriptyline — dosage adjustment may be necessary
• moderatepropofol — dosage adjustment may be necessary
• moderatelamotrigine — inhibits metabolism
• moderatediazepam — inhibits metabolism
• moderateethosuximide — inhibits metabolism
• moderatephenytoin — inhibits protein binding displacement