500 ML magnesium sulfate 40 MG/ML Injection

Drug interactions

The label outlines several drug interactions with esomeprazole, including those with antiretrovirals, warfarin, methotrexate, and others.

• majorrilpivirine — Contraindicated due to reduced antiviral effect and potential for drug resistance.
• majorwarfarin — Increased INR and prothrombin time, leading to abnormal bleeding and potential death.
• moderatemethotrexate — Elevated and prolonged serum concentrations of methotrexate, possibly leading to toxicities.
• majorclopidogrel — Reduced plasma concentrations of the active metabolite of clopidogrel and reduced platelet inhibition.
• moderatecitalopram — Increased exposure leading to an increased risk of QT prolongation.
• moderatecilostazol — Increased exposure of cilostazol and its active metabolite.
• moderatedigoxin — Potential for increased exposure of digoxin.
• moderatemycophenolate mofetil — Reduced exposure to the active metabolite, mycophenolic acid, possibly affecting organ rejection.
• moderatetacrolimus — Potentially increased exposure of tacrolimus, especially in certain metabolizers.