12 HR chlorpheniramine maleate 12 MG Extended Release Oral Tablet [Chlor-Trimeton]
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12 HR chlorpheniramine maleate 12 MG Extended Release Oral Tablet [Chlor-Trimeton]
12 MG · Extended Release Oral Tablet · oral
A form of chlorpheniramine →
12 HR chlorpheniramine maleate 12 MG Extended Release Oral Tablet [Chlor-Trimeton] — Substituted alkylamines. Strength, form, class, interactions & more.
![12 HR chlorpheniramine maleate 12 MG Extended Release Oral Tablet [Chlor-Trimeton]](https://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=65d4d7ea-c080-404e-9836-7d6bdcc5ea7d&name=cvs-44-689-1.jpg)
Active ingredient
Classification
Substituted alkylaminesHistamine-1 Receptor Antagonist
Drug interactions
Chlorpheniramine has several drug interactions that may lead to increased risks or reduced efficacy of concomitant medications.
- majorphenytoin — may increase phenytoin levels and toxicity
- majorserotonergic drugs — may result in serotonin syndrome
- majorMonoamine Oxidase Inhibitors (MAOIs) — can potentiate the effects of hydrocodone
- majormuscle relaxants — may enhance respiratory depression
- moderatediuretics — may reduce the efficacy of diuretics
- majorCYP3A4 inhibitors — can increase plasma concentration of hydrocodone
- majorCYP3A4 inducers — can decrease plasma concentration of hydrocodone
- majorbenzodiazepines and other CNS depressants — can increase risk of respiratory depression and sedation
- majoralcohol — can result in increased hydrocodone plasma levels and overdose
Source: RxNorm + openFDA + RxClass + FAERS · 2026
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