Rare diseases · Sign or symptom
Thin vermilion border
Decreased volume of lip
HP:0000233
What it means
Height of the vermilion of the medial part of the lip more than 2 SD below the mean, or apparently reduced height of the vermilion of the lip in the frontal view. The vermilion is the red part of the lips (and confusingly, the vermilion itself is also often referred to as being equivalent the lips).
The vermilion is the red part of the lips, and the vermilion border is the rim of paler skin that demarcates the vermilion from the rest of the skin of the face.
Rare diseases that can present with this88
Very common80–99%
31- 1q44microdeletion syndrome
- 9q33.3q34.11microdeletion syndrome
- Arthrogryposis multiplex congenita-whistling face syndrome
- Atypical Werner syndrome
- Baraitser-Winter cerebrofrontofacial syndrome
- Carey-Fineman-Ziter syndrome
- Charlie M syndrome
- Cornelia de Lange syndrome
- Craniolenticulosutural dysplasia
- Craniosynostosis-hydrocephalus-Arnold-Chiari malformation type I-radioulnar synostosis syndrome
- Difference of sex development-intellectual disability syndrome
- Distal deletion 1q syndrome
- Distal duplication 6p syndrome
- Edinburgh malformation syndrome
- Fetal valproate spectrum disorder
- Hutchinson-Gilford progeria syndrome
- Intellectual disability-balding-patella luxation-acromicria syndrome
- Maternal uniparental disomy of chromosome X syndrome
- Myhre syndrome
- Nicolaides-Baraitser syndrome
- Non-distal duplication 13q syndrome
- Paternal 20q13.2q13.3 microdeletion syndrome
- Progressive non-infectious anterior vertebral fusion
- Ring chromosome 10 syndrome
- Ring chromosome 7 syndrome
- Ruvalcaba syndrome
- Sanjad-Sakati syndrome
- Short stature-brachydactyly-obesity-global developmental delay syndrome
- SPECC1L-related hypertelorism syndrome
- Trisomy 18p syndrome
- Xq27.3q28duplication syndrome
Common30–79%
29- 16p12.1p12.3triplication syndrome
- 19p13.12microdeletion syndrome
- 19q13.11microdeletion syndrome
- 2q32q33deletion syndrome
- 2q37microdeletion syndrome
- Alport syndrome-intellectual disability-midface hypoplasia-elliptocytosis syndrome
- Branchioskeletogenital syndrome
- C syndrome
- CTCF-related neurodevelopmental disorder
- Distal duplication 5q syndrome
- Gómez-López-Hernández syndrome
- Growth delay due to insulin-like growth factor I resistance
- Hajdu-Cheney syndrome
- Lethal hemolytic anemia-genital anomalies syndrome
- LIG4 syndrome
- Mesomelic dwarfism-cleft palate-camptodactyly syndrome
- Monosomy 22 syndrome
- Oculocerebrofacial syndrome, Kaufman type
- PHIP-related behavioral problems-intellectual disability-obesity-dysmorphic features syndrome
- Pierpont syndrome
- Silver-Russell syndrome
- Silver-Russell syndrome due to maternal uniparental disomy of chromosome 7
- Tetralogy of Fallot
- Trisomy 8p syndrome
- Ulbright-Hodes syndrome
- Vascular Ehlers-Danlos syndrome
- X-linked intellectual disability, Nascimento type
- Yunis-Varon syndrome
- Zechi-Ceide syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Decreased volume of lip vermillion · Thin lips · Thin vermilion borders · Thin vermillion
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.