Rare diseases · Sign or symptom
Talipes equinovarus
Club feet
HP:0001762
What it means
Talipes equinovarus (also called clubfoot) typically has four main components: inversion and adduction of the forefoot; inversion of the heel and hindfoot; equinus (limitation of extension) of the ankle and subtalar joint; and internal rotation of the leg.
Clubfoot is a complex, multifactorial deformity with genetic and intrauterine factors. One popular theory postulates that a clubfoot is a result of intrauterine maldevelopment of the talus that leads to adduction and plantarflexion of the foot. On radiographic projection a clubfoot can be noted as parallel axes of talus and calcaneus. Fetal foot inversion refers to malposition of the foot originating during development involving inversion at the region of the metacarpals or more usually the subtalar joint and represents the prenatal sonographic equivalent of talipes equinovarus.
Rare diseases that can present with this146
Very common80–99%
15- Acromelic frontonasal dysplasia
- Autosomal dominant Charcot-Marie-Tooth disease type 2F
- Camptodactyly syndrome, Guadalajara type 2
- Crane-Heise syndrome
- De Barsy syndrome
- Familial clubfoot due to 17q23.1q23.2 microduplication
- Freeman-Sheldon syndrome
- Isolated tibial hemimelia
- Lissencephaly type 3-metacarpal bone dysplasia syndrome
- Microcephalic osteodysplastic dysplasia, Saul-Wilson type
- Microtriplication 11q24.1 syndrome
- Multiple pterygium-malignant hyperthermia syndrome
- Pseudodiastrophic dysplasia
- Richieri Costa-Pereira syndrome
- TARP syndrome
Common30–79%
62- 1q41q42microdeletion syndrome
- 9q33.3q34.11microdeletion syndrome
- Aase-Smith syndrome type 1
- Achondrogenesis type 1B
- Alpha-thalassemia-intellectual disability syndrome linked to chromosome 16
- Anophthalmia-megalocornea-cardiopathy-skeletal anomalies syndrome
- Atelosteogenesis type I
- Atelosteogenesis type III
- Autosomal dominant dopa-responsive dystonia
- Autosomal recessive Charcot-Marie-Tooth disease with hoarseness
- Autosomal recessive dopa-responsive dystonia
- Autosomal recessive spastic paraplegia type 55
- Autosomal recessive spastic paraplegia type 59
- Autosomal recessive spastic paraplegia type 66
- B3GALT6-related spondylodysplastic Ehlers-Danlos syndrome
- Bruck syndrome
- Campomelic dysplasia
- Carey-Fineman-Ziter syndrome
- Caudal regression syndrome
- Central core disease
- Charcot-Marie-Tooth disease type 4G
- Cloacal exstrophy
- COG1-CDG
- Congenital limbs-face contractures-hypotonia-developmental delay syndrome
- Contractures-developmental delay-Pierre Robin syndrome
- Diastrophic dysplasia
- Distal deletion 15q syndrome
- Dysplastic cortical hyperostosis, Al-Gazali type
- Dyssegmental dysplasia, Silverman-Handmaker type
- Early-onset seizures-distal limb anomalies-facial dysmorphism-global developmental delay syndrome
- Femoral-facial syndrome
- Friedreich ataxia
- Genitopatellar syndrome
- Giant axonal neuropathy
- Hypotonia-speech impairment-severe cognitive delay syndrome
- Isolated fibular hemimelia
- Kyphoscoliosis-lateral tongue atrophy-hereditary spastic paraplegia syndrome
- Kyphoscoliotic Ehlers-Danlos syndrome due to lysyl hydroxylase 1 deficiency
- Lethal Kniest-like dysplasia
- Loeys-Dietz syndrome
- MEHMO syndrome
- Moderate multiminicore disease with hand involvement
- Moebius syndrome
- Monosomy 18q syndrome
- Mosaic trisomy 9 syndrome
- Multiple epiphyseal dysplasia type 4
- Musculocontractural Ehlers-Danlos syndrome
- Native American myopathy
- Parkinsonian-pyramidal syndrome
- Pelvis-shoulder dysplasia
- Roussy-Lévy syndrome
- Spondylocarpotarsal synostosis
- Spondylodysplastic Ehlers-Danlos syndrome
- Stüve-Wiedemann syndrome
- Tetrasomy 5p syndrome
- Trisomy 18 syndrome
- Ulbright-Hodes syndrome
- Vascular Ehlers-Danlos syndrome
- Wolf-Hirschhorn syndrome
- X-linked alpha-thalassemia-intellectual disability syndrome
- X-linked intellectual disability-ataxia-apraxia syndrome
- X-linked intellectual disability, Stocco Dos Santos type
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Club foot · Clubbing of feet · Clubfeet · Clubfoot · Equinovarus · Fetal foot inversion · Foetal foot inversion · Foot, talipes equinovarus
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.